Applied Computational Cancer Research

Prof. Dr. Florian Rambow

“Wolfgang und Gertrud Böttcher Stiftungsprofessur”
Stiftung Universitätsmedizin Essen

The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.

Contact

Girardethaus
Girardetstr. 8
House 8, 2nd floor
45131 Essen

Prof. Dr. Florian Rambow
Office

Projects

Recent Publications - see all...

  1. S. Egea-Rodriguez, R. Varaljai, T. M. Nordmann, R. Lubis, M. Philip, F. Rambow, A. Roesch, M. Flaig, S. Horn, R. Stoll, F. Zhao, A. Paschen, B. Klebl, I. D. Hickson, D. Schadendorf, M. Mann, and I. Helfrich. RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma. Clin Transl Med. 2025. [doi] [url]
    BibTeX
    @article{RN263,
      author = {Egea-Rodriguez, S. and Varaljai, R. and Nordmann, T. M. and Lubis, R. and Philip, M. and Rambow, F. and Roesch, A. and Flaig, M. and Horn, S. and Stoll, R. and Zhao, F. and Paschen, A. and Klebl, B. and Hickson, I. D. and Schadendorf, D. and Mann, M. and Helfrich, I.},
      title = {RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma},
      journal = {Clin Transl Med},
      volume = {15},
      number = {1},
      pages = {e70094},
      issn = {2001-1326 (Electronic)
      2001-1326 (Linking)},
      doi = {10.1002/ctm2.70094},
      url = {https://www.ncbi.nlm.nih.gov/pubmed/39812592},
      year = {2025},
      type = {Journal Article}
    }
    
  2. J. M. Placke, J. Bottek, R. Varaljai, B. Shannan, S. Scharfenberg, C. Krisp, P. Spangenberg, C. Soun, D. Siemes, L. Borgards, F. Hoffmann, F. Zhao, A. Paschen, H. Schlueter, F. von Eggeling, I. Helfrich, F. Rambow, S. Ugurel, A. Tasdogan, D. Schadendorf, D. R. Engel, and A. Roesch. Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma. Br J Dermatol. 2024. [doi] [url]
    BibTeX
    @article{RN264,
      author = {Placke, J. M. and Bottek, J. and Varaljai, R. and Shannan, B. and Scharfenberg, S. and Krisp, C. and Spangenberg, P. and Soun, C. and Siemes, D. and Borgards, L. and Hoffmann, F. and Zhao, F. and Paschen, A. and Schlueter, H. and von Eggeling, F. and Helfrich, I. and Rambow, F. and Ugurel, S. and Tasdogan, A. and Schadendorf, D. and Engel, D. R. and Roesch, A.},
      title = {Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma},
      journal = {Br J Dermatol},
      issn = {1365-2133 (Electronic)
      0007-0963 (Linking)},
      doi = {10.1093/bjd/ljae433},
      url = {https://www.ncbi.nlm.nih.gov/pubmed/39739311},
      year = {2024},
      type = {Journal Article}
    }
    
  3. S. D. Shelton, S. House, L. Martins Nascentes Melo, V. Ramesh, Z. Chen, T. Wei, X. Wang, C. B. Llamas, S. S. K. Venigalla, C. J. Menezes, G. Allies, J. Krystkiewicz, J. Rosler, S. W. Meckelmann, P. Zhao, F. Rambow, D. Schadendorf, Z. Zhao, J. G. Gill, R. J. DeBerardinis, S. J. Morrison, A. Tasdogan, and P. Mishra. Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis. Sci Adv. 2024. [doi] [url]
    BibTeX
    @article{RN174,
      author = {Shelton, S. D. and House, S. and Martins Nascentes Melo, L. and Ramesh, V. and Chen, Z. and Wei, T. and Wang, X. and Llamas, C. B. and Venigalla, S. S. K. and Menezes, C. J. and Allies, G. and Krystkiewicz, J. and Rosler, J. and Meckelmann, S. W. and Zhao, P. and Rambow, F. and Schadendorf, D. and Zhao, Z. and Gill, J. G. and DeBerardinis, R. J. and Morrison, S. J. and Tasdogan, A. and Mishra, P.},
      title = {Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis},
      journal = {Sci Adv},
      volume = {10},
      number = {44},
      pages = {eadk8801},
      issn = {2375-2548 (Electronic)
      2375-2548 (Linking)},
      doi = {10.1126/sciadv.adk8801},
      url = {https://www.ncbi.nlm.nih.gov/pubmed/39485847},
      year = {2024},
      type = {Journal Article}
    }
    
  4. Yichao Hua, Linqian Weng, Fang Zhao, and Florian Rambow. SeuratExtend: Streamlining Single-Cell RNA-Seq Analysis Through an Integrated and Intuitive Framework. bioRxiv. 2024. Cold Spring Harbor Laboratory. [doi] [url]
    BibTeX
    @article{Hua2024.08.01.606144,
      author = {Hua, Yichao and Weng, Linqian and Zhao, Fang and Rambow, Florian},
      title = {SeuratExtend: Streamlining Single-Cell RNA-Seq Analysis Through an Integrated and Intuitive Framework},
      elocation-id = {2024.08.01.606144},
      year = {2024},
      doi = {10.1101/2024.08.01.606144},
      publisher = {Cold Spring Harbor Laboratory},
      url = {https://www.biorxiv.org/content/early/2024/08/04/2024.08.01.606144},
      eprint = {https://www.biorxiv.org/content/early/2024/08/04/2024.08.01.606144.full.pdf},
      journal = {bioRxiv}
    }
    
  5. C. Dobersalske, L. Rauschenbach, Y. Hua, C. Berliner, A. Steinbach, A. Gruneboom, K. D. Kokkaliaris, D. H. Heiland, P. Berger, S. Langer, C. L. Tan, M. Stenzel, S. Landolsi, F. Weber, M. Darkwah Oppong, R. A. Werner, H. Gull, T. Schroder, T. Linsenmann, A. K. Buck, M. Gunzer, M. Stuschke, K. Keyvani, M. Forsting, M. Glas, J. Kipnis, D. A. Steindler, H. C. Reinhardt, E. W. Green, M. Platten, A. Tasdogan, K. Herrmann, F. Rambow, I. Cima, U. Sure, and B. Scheffler. Cranioencephalic functional lymphoid units in glioblastoma. Nat Med. 2024. [doi] [url]
    BibTeX
    @article{RN262,
      author = {Dobersalske, C. and Rauschenbach, L. and Hua, Y. and Berliner, C. and Steinbach, A. and Gruneboom, A. and Kokkaliaris, K. D. and Heiland, D. H. and Berger, P. and Langer, S. and Tan, C. L. and Stenzel, M. and Landolsi, S. and Weber, F. and Darkwah Oppong, M. and Werner, R. A. and Gull, H. and Schroder, T. and Linsenmann, T. and Buck, A. K. and Gunzer, M. and Stuschke, M. and Keyvani, K. and Forsting, M. and Glas, M. and Kipnis, J. and Steindler, D. A. and Reinhardt, H. C. and Green, E. W. and Platten, M. and Tasdogan, A. and Herrmann, K. and Rambow, F. and Cima, I. and Sure, U. and Scheffler, B.},
      title = {Cranioencephalic functional lymphoid units in glioblastoma},
      journal = {Nat Med},
      issn = {1546-170X (Electronic)
      1078-8956 (Linking)},
      doi = {10.1038/s41591-024-03152-x},
      url = {https://www.ncbi.nlm.nih.gov/pubmed/39085419},
      year = {2024},
      type = {Journal Article}
    }
    

Team

Photo of Florian Rambow

Prof. Dr. Florian Rambow

florian.rambow@uk-essen.de

Administration

Photo of Andrea Tonk

Andrea Tonk

andrea.tonk@uk-essen.de
Phone: +4920172377825

Lab Manager

Photo of Samira Makhzami

M.Sc. Samira Makhzami

samira.rambow-makhzami@uk-essen.de

Researchers

Photo of Yichao Hua

Dr. Yichao Hua

yichao.hua@uk-essen.de

Photo of Peihua Zhao

Dr. Peihua Zhao

peihua.zhao@uk-essen.de

Photo of Carl Maximilian Thielmann

Dr. Carl Maximilian Thielmann

carl.thielmann@uk-essen.de
Associated UMEA Clinician Scientist

Research Assistants

Photo of Lea Otte

M.Sc. Lea Otte, Ph.D. Candidate

lea.otte@uk-essen.de

Photo of Hua Dong

M.Sc. Hua Dong, Ph.D. Candidate

hua.dong@uk-essen.de

Tech

Photo of Marcel Bargull

B.Sc. Marcel Bargull

marcel.bargull@uk-essen.de