Applied Computational Cancer Research

Prof. Dr. Florian Rambow

“Wolfgang und Gertrud Böttcher Stiftungsprofessur”
Stiftung Universitätsmedizin Essen

The ACCR group headed by Prof. Dr. Florian Rambow focuses on resolving and perturbing cancer cell fate decisions to prevent cancer progression and therapy resistance. We leverage the power of spatially resolved single-cell approaches in combination with computational biology to investigate cell state plasticity and the contribution of the tumor microenvironment. Our primary aim is to advance translational precision oncology.

Contact

Girardethaus
Girardetstr. 8
House 8, 2nd floor
45131 Essen

Prof. Dr. Florian Rambow
Office

Projects

Recent Publications - see all...

K. Theunis, S. Vanuytven, I. Claes, J. Geurts, F. Rambow, D. Brown, M. Van Der Haegen, O. Marin-Bejar, A. Rogiers, N. Van Raemdonck, E. Leucci, J. Demeulemeester, A. Sifrim, J. C. Marine, and T. Voet. Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones. Nucleic Acids Res. 2025. [doi] [url]

BibTeX

@article{RN267,
  author = {Theunis, K. and Vanuytven, S. and Claes, I. and Geurts, J. and Rambow, F. and Brown, D. and Van Der Haegen, M. and Marin-Bejar, O. and Rogiers, A. and Van Raemdonck, N. and Leucci, E. and Demeulemeester, J. and Sifrim, A. and Marine, J. C. and Voet, T.},
  title = {Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones},
  journal = {Nucleic Acids Res},
  volume = {53},
  number = {6},
  issn = {1362-4962 (Electronic)
  0305-1048 (Print)
  0305-1048 (Linking)},
  doi = {10.1093/nar/gkaf173},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/40138718},
  year = {2025},
  type = {Journal Article}
}

Y. Hua, L. Weng, F. Zhao, and F. Rambow. SeuratExtend: streamlining single-cell RNA-seq analysis through an integrated and intuitive framework. Gigascience. 2025. [doi] [url]

BibTeX

@article{RN265,
  author = {Hua, Y. and Weng, L. and Zhao, F. and Rambow, F.},
  title = {SeuratExtend: streamlining single-cell RNA-seq analysis through an integrated and intuitive framework},
  journal = {Gigascience},
  volume = {14},
  issn = {2047-217X (Electronic)
  2047-217X (Linking)},
  doi = {10.1093/gigascience/giaf076},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/40627366},
  year = {2025},
  type = {Journal Article}
}

S. Dandou, J. A. Vendrell, J. Solassol, B. Louveau, C. Lebbe, S. Mourah, F. Rambow, E. Richard, S. Du Manoir, A. Mange, P. J. Coopman, O. Radulescu, and R. M. Larive. MelanoDB: A dataset of clinical and molecular features of patients with advanced melanoma treated with MAPK inhibitors. Sci Data. 2025. [doi] [url]

BibTeX

@article{RN266,
  author = {Dandou, S. and Vendrell, J. A. and Solassol, J. and Louveau, B. and Lebbe, C. and Mourah, S. and Rambow, F. and Richard, E. and Du Manoir, S. and Mange, A. and Coopman, P. J. and Radulescu, O. and Larive, R. M.},
  title = {MelanoDB: A dataset of clinical and molecular features of patients with advanced melanoma treated with MAPK inhibitors},
  journal = {Sci Data},
  volume = {12},
  number = {1},
  pages = {1144},
  issn = {2052-4463 (Electronic)
  2052-4463 (Linking)},
  doi = {10.1038/s41597-025-05291-3},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/40615439},
  year = {2025},
  type = {Journal Article}
}

S. Egea-Rodriguez, R. Varaljai, T. M. Nordmann, R. Lubis, M. Philip, F. Rambow, A. Roesch, M. Flaig, S. Horn, R. Stoll, F. Zhao, A. Paschen, B. Klebl, I. D. Hickson, D. Schadendorf, M. Mann, and I. Helfrich. RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma. Clin Transl Med. 2025. [doi] [url]

BibTeX

@article{RN263,
  author = {Egea-Rodriguez, S. and Varaljai, R. and Nordmann, T. M. and Lubis, R. and Philip, M. and Rambow, F. and Roesch, A. and Flaig, M. and Horn, S. and Stoll, R. and Zhao, F. and Paschen, A. and Klebl, B. and Hickson, I. D. and Schadendorf, D. and Mann, M. and Helfrich, I.},
  title = {RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma},
  journal = {Clin Transl Med},
  volume = {15},
  number = {1},
  pages = {e70094},
  issn = {2001-1326 (Electronic)
  2001-1326 (Linking)},
  doi = {10.1002/ctm2.70094},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/39812592},
  year = {2025},
  type = {Journal Article}
}

J. M. Placke, J. Bottek, R. Varaljai, B. Shannan, S. Scharfenberg, C. Krisp, P. Spangenberg, C. Soun, D. Siemes, L. Borgards, F. Hoffmann, F. Zhao, A. Paschen, H. Schlueter, F. von Eggeling, I. Helfrich, F. Rambow, S. Ugurel, A. Tasdogan, D. Schadendorf, D. R. Engel, and A. Roesch. Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma. Br J Dermatol. 2024. [doi] [url]

BibTeX

@article{RN264,
  author = {Placke, J. M. and Bottek, J. and Varaljai, R. and Shannan, B. and Scharfenberg, S. and Krisp, C. and Spangenberg, P. and Soun, C. and Siemes, D. and Borgards, L. and Hoffmann, F. and Zhao, F. and Paschen, A. and Schlueter, H. and von Eggeling, F. and Helfrich, I. and Rambow, F. and Ugurel, S. and Tasdogan, A. and Schadendorf, D. and Engel, D. R. and Roesch, A.},
  title = {Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma},
  journal = {Br J Dermatol},
  issn = {1365-2133 (Electronic)
  0007-0963 (Linking)},
  doi = {10.1093/bjd/ljae433},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/39739311},
  year = {2024},
  type = {Journal Article}
}